Bisono^®tape has been designed to have the optimum combination of skin permeability of drug and adhesion properties using poly（iso-butylene）rubber adhesive. Once daily administration of Bisono^®tape produced a sustained release of active ingredient bisoprolol through skin showed moderate change in blood concentration and demonstrated antihypertensive effects for twenty-four hours. It is also expected that Bisono^®tape contributes to maintain the medication of patients with dysphagia and/or poor compliance to medication and improves patient adherence. This article reviews the formulation design, clinical results and features of Bisono^®tape.